Scientist, Neurodegeneration

<div class="content-intro"><h2><strong>Our Mission</strong></h2> <p>Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life.</p> <p>For more information, see our website at <a href="https://altoslabs.com/" target="_blank">altoslabs.com.</a></p> <h2><strong>Our Value</strong></h2> <p>Our Single Altos Value: <strong>Everyone Owns Achieving Our Inspiring Mission</strong>.</p> <h2><strong>Diversity at Altos</strong></h2> <p>Altos Labs has been named one of the Top 3 Biotech Companies and ranked for the second year on the Forbes 2026 Best Startups in America list. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment.</p></div><h2><strong>What You Will Contribute To Altos</strong></h2> <p> </p> <p>Join Altos Labs at the Bay Area Discovery Science center and play a pivotal role in our mission to reverse brain aging. We are seeking a driven neuroscientist with deep expertise in neurodegeneration to join our highly collaborative, fast-paced team. In this role, you will work closely with cross-functional experts to discover and validate optimal therapeutic targets for the treatment of neurodegenerative diseases. If you are passionate about translating complex biology into transformative therapies, we want you on our team.</p> <p><strong>Responsibilities</strong></p> <ul> <li><strong>Lead the Science:</strong> Act as the scientific lead for a key segment of our neurodegeneration portfolio. You will shape critical research questions, design robust experiments, and drive studies through to actionable, interpretable conclusions.</li> <li><strong>Model Disease Biology:</strong> Design and execute <em>in vivo</em> studies using rodent models of neurodegeneration, strategically selecting models, timepoints, and endpoints tailored to specific biological questions and program stages.</li> <li><strong>Analyze Complex Tissue:</strong> Process and analyze both rodent and human brain tissue. This includes dissection, regional sampling, fixation, cryopreservation, sectioning, and comprehensive downstream characterization (molecular, biochemical, and histological).</li> <li><strong>Innovate Quantitative Readouts:</strong> Develop and apply precise quantitative readouts for pathology and disease biology, tracking markers such as protein aggregation, neuroinflammation, cell loss, and vascular integrity.</li> <li><strong>Collaborate Across Disciplines:</strong> Partner closely with internal experts—including <em>in vivo</em> pharmacology, histology, molecular biology, computational, and program management teams—as well as external collaborators and CROs to seamlessly deliver on shared timelines.</li> <li><strong>Champion Scientific Rigor:</strong> Establish and promote the highest technical and cultural standards across our scientific functions. You will help embed foundational practices—such as experimental rigor, blinding, randomization, data provenance, and reproducibility—into our day-to-day operations.</li> <li><strong>Drive Strategic Decisions:</strong> Actively contribute to program strategy and high-level decision-making, providing critical input on go/no-go recommendations. We value transparent communication, so you will be expected to flag risks early and candidly.<