Associate Director, Clinical Operations (Contract)

<div class="content-intro"><p><em>Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, </em><em>is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions.</em></p> <p><em> </em><em>Headquartered in Boston, Massachusetts, Centessa was recognized as a <strong>Great Place to Work</strong>® in 2026.</em></p></div><p><strong>Description of Role</strong></p> <p><span class="TextRun SCXW169162308 BCX0" lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW169162308 BCX0">The (contract-to-hire) Associate Director, Clinical Operations, will provide leadership and operational oversight for assigned clinical trials and programs throughout the clinical development lifecycle. This role is a temporary position with the potential to convert to a permanent role, supporting strategic planning, execution, quality, and compliance, ensuring study objectives are met on time, within budget, and according to applicable regulatory standards (e.g., GCP, ICH). The successful candidate will collaborate cross-functionally and support </span><span class="NormalTextRun SCXW169162308 BCX0">Centessa’s</span><span class="NormalTextRun SCXW169162308 BCX0"> mission to bring transformational medicines to patients.</span></span><span class="EOP Selected SCXW169162308 BCX0" data-ccp-props="{}"> </span></p> <p><strong>Key Responsibilities</strong></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Lead and oversee end-to-end clinical trial operations from study start-up through close-out for Centessa’s Orexin development programs.</span></li> <li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Develop and execute operational plans, timelines, and performance metrics to support successful delivery of assigned studies.</li> <li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Partner closely with Clinical Development, Regulatory Affairs, Data Management, Biostatistics, Safety, and other functions to ensure aligned and efficient trial execution.</li> <li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"hybridMultilevel"}" data-aria-posinset="1" data-aria-level="1">Contribute to the development and review of key study documents, including protocols, informed consent forms, monitoring plans, EDC specifications, and statistical analysis plans.</li> <li data-leveltext="" data-font="Symbol" data-listid="2"