<div class="content-intro">Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions. Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work® in 2026.</div>Description of Role Centessa is currently seeking an (Associate) Director, Clinical Supply Chain. The successful candidate will develop and implement strategies to deliver Investigational Product (IP) in support of several clinical programs. Reporting to the Senior Director, Clinical Supply Chain this individual will develop strong collaborative relationships with several internal departments as well as third-party procurement, packaging, and distribution providers to align objectives and implement decisions which ensure clinical supply. The successful candidate will demonstrate strong attention to detail, which they will apply to the development and routine maintenance of clinical forecasts, inventory databases and IRT systems providing daily oversight of clinical supplies. Management and travel to CDMOs both domestically and internationally may be required. Key Responsibilities Leadership: <ul> <li>Develop and update clinical supply strategies as needed to meet corporate demands</li> <li>Develop/maintain strong collaborative relationships with internal departments and external CDMOs</li> <li>Identify potential supply chain risks and develop & implement negotiated mitigation strategies</li> <li>Manage study/program budget, contracts and change orders and track spend against budget</li> </ul> Execution: <ul> <li>Develop and working with Clinical, regularly update forecast/demand plans for late phase clinical trials.</li> <li>Collaborate with Quality, Clinical, CMC and external CDMOs to develop and approve clinical labels.</li> <li>Manage CDMO packaging/labeling schedules to ensure availability of clinical supplies.</li> <li>Interact regularly with third-party providers to manage logistics & licenses required to ship materials from manufacturing to bulk storage facilities, courier depots and investigator sites.</li> <li>Work with CMC and QA to facilitate document transfer required for IP/QP release by CDMOs</li> <li>Manage and track clinical supply inventory either manually or through an Interactive Response Technology (IRT) system.</li> <li>Manage Product Recovery pending investigation of IP from investigator sites as needed.</li> </ul> Collaboration: <ul> <li>Effectively collaborate and communication across multiple functional areas, bringing a sufficient breadth of knowledge.</li> <li>Monitor shelf-life and expiry dating and coordinate retest extension with analytical team to ensure continuous supply.</li> <li>Manage investigation, reporting and communication of outcomes from temperature excursions and product complaints.</li> <li>Author and/or r

Associate Director, Clinical Supply Chain

Job Description