<div class="content-intro">Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions. Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work® in 2026.</div>Description of Role Centessa is seeking a Manager, Clinical Supply Chain to support end-to-end planning, execution, and maintenance of uninterrupted clinical supply — including investigational product (IP), comparators, and ancillary materials — across assigned clinical programs. This role ensures compliance with GxP requirements, study timelines, and budgets while partnering cross-functionally with Clinical Operations, CMC, Quality, Regulatory, Finance, and external vendors. Reporting to the Senior Director, Clinical Supply Chain, the individual will build strong relationships with internal teams and third-party suppliers to align objectives and support successful trial execution, with particular attention to clinical forecasts, inventory systems, and IRT tools. Key Responsibilities Clinical Supply Planning & Execution <ul> <li>Contribute to the development and execution of clinical supply strategies for early- to mid-phase clinical trials (Phase 1–3 as applicable).</li> <li>Manage clinical supply plans, demand forecasts, and inventory strategies — including tracking through Interactive Response Technology (IRT) systems — in alignment with protocol requirements and enrollment projections.</li> <li>Support packaging, labeling, distribution, and resupply activities for investigational products and comparators.</li> <li>Ensure on-time delivery of clinical supplies to depots and clinical sites globally.</li> </ul> Vendor & CDMO Management <ul> <li>Partner with Quality, Clinical, CMC, and external CDMOs to develop, review, and approve clinical labels, and support CDMO packaging/labeling schedules to ensure supply availability.</li> <li>Interact regularly with third-party providers to manage the logistics and licenses required to ship materials from manufacturing to bulk storage facilities, courier depots, and investigator sites.</li> <li>Collaborate with CMC and QA to facilitate the document transfer required for IP/QP release by CDMOs.</li> </ul> Quality & Compliance Support <ul> <li>Monitor shelf-life and expiry dating, and coordinate retest/extension activities with the analytical team to ensure continuous supply.</li> <li>Manage the investigation, reporting, and communication of outcomes from temperature excursions and product complaints.</li> <li>Support product recovery activities pending investigation of IP from investigator sites, as needed.</li> </ul> Cross-Functional Collaboration & Representation <ul> <li>Communicate effectively across functional areas, applying a solid working knowledge of clinical supply chain processes

Manager, Clinical Supply Chain

Job Description