<div class="content-intro">Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions. Headquartered in Boston, Massachusetts, Centessa was recognized as a Great Place to Work® in 2026.</div>Description of Role The MSL will serve as a field-based scientific expert responsible for engaging with healthcare professionals (HCPs), supporting clinical development, and ensuring alignment with Centessa’s strategic medical objectives. This role is critical in translating complex scientific data into meaningful clinical insights and fostering compliant, evidence-based dialogue with thought leaders. Key Responsibilities Scientific Expertise & Thought Leader Engagement <ul> <li>Maintain a high level of therapeutic area expertise and scientific knowledge relevant to Centessa’s pipeline and marketed products in alignment with Medical Affairs strategic objectives</li> <li>Engage in compliant, non-promotional scientific exchange with key opinion leaders (KOLs), investigators, and other HCPs</li> <li>Serve as a trusted scientific resource to external stakeholders, providing accurate and balanced medical information</li> <li>Deliver company-approved, high-quality medical/scientific presentations to a variety of audiences including formulary committees and healthcare professionals.</li> <li>Provide medical/scientific support for critical Centessa activities including speaker training, advisory boards, and sales training as appropriate</li> <li>Ensure accurate, timely, and compliant documentation of field-based activities in accordance with MSL organization guidelines Clinical Trials Support</li> <li>Collaborate with Clinical Operations to identify and evaluate potential clinical trial sites and investigators based on scientific expertise, patient population, and alignment with study objectives</li> <li>Provide scientific education and protocol-specific training to investigators and site staff during site initiation visits, ensuring thorough understanding of study rationale and endpoints</li> <li>Maintain ongoing engagement with trial sites and investigators to facilitate successful execution of clinical trial objectives, provide ongoing scientific support, address protocol-related inquiries, and ensure high-quality data generation Medical Conference Attendance & Coverage</li> <li>Attend relevant scientific and medical congresses to stay current with emerging data and trends</li> <li>Provide real-time insights and post-conference reports to internal teams</li> <li>Support Centessa’s presence at congresses through development of pre-conference plans, booth coverage, symposia attendance, and KOL engagement</li> <li>Senior MSLs will be responsible for leading strategic conference planning, execution, and reporting Scientific Materials Development</li> <li>Contribute to the developmen

Medical Science Liaison (MSL) – North Central

Job Description