Senior Director, Drug Product CMC

<div class="content-intro"><p><em>Centessa Pharmaceuticals, a wholly owned subsidiary of Eli Lilly and Company, </em><em>is a clinical-stage company developing orexin receptor 2 (OX2R) agonists as a new class of medicines for the treatment of narcolepsy and potentially other sleep-wake disorders. Centessa’s lead investigational candidate – cleminorexton (formerly ORX750) – is being developed for narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Centessa's OX2R agonist portfolio includes additional clinical and preclinical-stage assets with potential utility across a broader range of neurological, neurodegenerative, and neuropsychiatric conditions.</em></p> <p><em> </em><em>Headquartered in Boston, Massachusetts, Centessa was recognized as a <strong>Great Place to Work</strong>® in 2026.</em></p></div><p><strong>Description of Role</strong></p> <p><span data-contrast="auto">Centessa is seeking a Senior Director of Drug Product within the CMC group. The successful candidate will have a demonstrated, proven track record of designing high performance nonclinical and clinical formulations as well as managing CROs and CDMOs. The candidate should also have hands-on experience in developing and manufacturing nonclinical and clinical small molecule drug products to support Phase I to Phase III. </span><span data-ccp-props="{}"> </span></p> <p><span data-contrast="auto">Reporting to the Executive Director, CMC, this position will primarily lead work with external vendors and oversee nonclinical formulation development, with flexibility to support clinical drug product development, across programs to meet company deliverables and timelines. Travel to domestic and international vendors required.</span><span data-ccp-props="{}"> </span></p> <p><strong>Key Responsibilities</strong></p> <ul> <li><span data-contrast="auto">Directly manage external vendors, such as Contract Research Organizations (CROs) and Contract Development and Manufacturing Organizations (CDMOs) to: </span><span data-ccp-props="{"469777462":[720],"469777927":[0],"469777928":[8]}"> </span> <ul> <li><span data-contrast="auto">Execute physiochemical characterization and pre-formulation studies for New Chemical Entities (NCEs).</span></li> <li data-leveltext="o" data-font="Courier New" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":1080,"335559991":360,"469769226":"Courier New","469769242":[9675],"469777803":"left","469777804":"o","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="2">Design and develop nonclinical formulations of drug candidates (oral, subcutaneous, and intravenous) to ensure stability, bioavailability and effective drug delivery in animal models. </li> <li data-leveltext="o" data-font="Courier New" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":1080,"335559991":360,"469769226":"Courier New","469769242":[9675],"469777803":"left","469777804":"o","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="2">Design and oversee execution of nonclinical formulation stability and compatibility studies.</li> <li>Support clinical formulation development of oral solid dosage forms, as needed.<span data-ccp-props="{"469777462":[1440],"469777927":[0],"469777928":[8]}"> </span></li> </ul> </li> <li><span data-contrast="auto">Author and/or review and approve development and dose preparation protocols and reports.</span></li> <li data-leveltext="" data-font="Symbol" data-listid="2" data-list-defn-props="{"335552541":1,"335559685":360,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803"